Journal article
Barriers and strategies to achieve a cure for HIV
MC Pitman, JSY Lau, JH McMahon, SR Lewin
Lancet HIV | ELSEVIER INC | Published : 2018
Abstract
9 years since the report of a cure for HIV after C-C chemokine receptor type 5 Δ32 stem cell transplantation, no other case of HIV cure has been reported, despite much research. However, substantial progress has been made in understanding the biology of the latent HIV reservoir, and in measuring the amount of virus that persists after antiretroviral therapy (ART) with increasingly sophisticated approaches. This knowledge is being translated into a long pipeline of clinical trials seeking to reduce viral persistence in participants on suppressive treatment and ultimately to allow safe cessation of ART. In this Review, we discuss the main barriers preventing the development of an HIV cure, met..
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Grants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
MCP has a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (1114265) and Royal Australasian College of Physicians NHMRC CRB Blackburn Scholarship. JSYL has an NHMRC Postgraduate Scholarship (1151607). JHM has an NHMRC Early Career Fellowship (1111099). SRL is an NHMRC Practitioner Fellow (1042654) and is supported by the National Institutes of Health Delaney AIDS Research Enterprise (UM1 AI126611-01) and the American Foundation for AIDS Research (109226-58 RGRL). The funder of this study had no role in the design of the report, literature review, writing of the report, or the decision to submit the paper for publication. SRL had final responsibility for the decision to submit for publication.